pentobarbital will lessen the extent or result of trazodone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
pentobarbital will minimize the extent or impact of diltiazem by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
Keep track of Intently (one)pentobarbital will lessen the extent or impact of benzhydrocodone/acetaminophen by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Carefully. Warning when discontinuing CYP3A4 inducers which are coadministered with benzhydrocodone (prodrug of hydrocodone); plasma concentrations of hydrocodone might enhance and can result in most likely deadly respiratory despair.
Warning when discontinuing CYP3A4 inducers which might be coadministered with benzhydrocodone (prodrug of hydrocodone); plasma concentrations of hydrocodone might maximize and may result in likely fatal respiratory melancholy.
pentobarbital will minimize the extent or effect of estradiol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
pentobarbital improves toxicity of ifosfamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. CYP3A4 inducers may possibly enhance the metabolism click here of ifosfamide to its Lively alkylating metabolites.
Contraindicated (one)pentobarbital decreases levels of panobinostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Sturdy CYP3A4 inducers can reduce panobinostat levels by ~70% and lead to procedure failure.
pentobarbital will minimize the level or effect of methadone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
pentobarbital will decrease the extent or influence of efavirenz by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Unfamiliar.
Contraindicated. The therapeutic outcome of elbasvir/grazoprevir could possibly be decreased if coadministered with robust CYP3A inducers and is also thus contraindicated.
pentobarbital will reduce the extent or impact of tamoxifen by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
pentobarbital will decrease the extent or influence of ondansetron by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. No dosage adjustment for ondansetron is recommended for individuals on these drugs.
pentobarbital will minimize the extent or effect of lefamulin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Stay clear of coadministration of lefamulin with powerful or reasonable CYP3A inducers Except if the gain outweighs pitfalls. Observe for reduced efficacy.
pentobarbital will lessen the extent or impact of eltrombopag by influencing hepatic enzyme CYP2C9/ten metabolism. Use Caution/Watch.